Bacterial outer membrane vesicles suppress tumor by interferon-γ-mediated antitumor response > 연구성과

본문 바로가기

연구성과
연구성과

Bacterial outer membrane vesicles suppress tumor by interferon-γ-media…

첨부파일
  • 첨부된 파일이 없습니다.
  • 저널명Nature Comm. 8, Article number: 626 (2017) doi:10.1038/s41467-017-00729-8
    • 담당교수[2017년 9월] 고용송 교수연구실
    • 조회658
    • 작성자최고관리자
    • 2017-10-17

    본문

    Gram-negative bacteria actively secrete outer membrane vesicles, spherical nano-meter-sized proteolipids enriched with outer membrane proteins, to the surroundings. Outer membrane vesicles have gained wide interests as non-living complex vaccines or delivery vehicles. However, no study has used outer membrane vesicles in treating cancer thus far. Here we investigate the potential of bacterial outer membrane vesicles as therapeutic agents to treat cancer via immunotherapy. Our results show remarkable capability of bacterial outer membrane vesicles to effectively induce long-term antitumor immune responses that can fully eradicate established tumors without notable adverse effects. Moreover, systematically administered bacterial outer membrane vesicles specifically target and accumulate in the tumor tissue, and subsequently induce the production of antitumor cytokines CXCL10 and interferon-γ. This antitumor effect is interferon-γ dependent, as interferon-γ-deficient mice could not induce such outer membrane vesicle-mediated immune response. Together, our results herein demonstrate the potential of bacterial outer membrane vesicles as effective immunotherapeutic agent that can treat various cancers without apparent adverse effects.

    790-784 SAN 31, HYOJA-DONG, NAM-GU, POHANG, GYUNGBUK. KOREA 생체분자기능연구사업단 TEL : 054-279-2997

    COPYRIGHT 2016 POSTECH. Department of Life Sciences. All RIGHTS RESERVED. 관리자