[2019 Spring Life Sciences & IBB Seminar]
▶Subject: Re-evaluating extracellular vesicle-mediated miRNA transfer and regulation in cancer and HIV infection: context matters
▶Speaker: Prof. Kenneth Witwer (The Johns Hopkins University School of Medicine)
▶Date: 4:30PM/Apr. 19(Fri.)/2019
▶Place: Auditorium(1F), Postech Biotech Center
Re-evaluating extracellular vesicle-mediated miRNA transfer and regulation in cancer and HIV infection: context matters
Extracellular vesicles (EVs) are lipid bilayer-delimited particles released by all known cell types and are thought to exert effects in biological systems in part by transfer of small regulatory RNAs including microRNAs (miRNAs) from one cell to another. While biological effects of EVs are increasingly accepted, the stoichiometry of RNA transfer and RNA-mediated regulation do not always seem to match. The question is: how can we transfer enough miRNA into a recipient cell to achieve a desired effect? In this presentation, we will review what is known about a master of RNA transfer, the retrovirus known as HIV. We will also examine recent findings about the subcellular distribution and activities of miRNAs within the cell and what these findings mean for EV-mediated extracellular RNA communication.
▶Inquiry: Prof. Yong Song Gho (279-2345)
* This seminar will be given in English.
Please refrain from taking photos during seminars. *