[Life Sciences Seminar]
▶Subject: Proteostasis control through translocational regulation
▶Speaker: Prof. Sang-Wook Kang (Department of Biomedical Sciences, University of Ulsan College of Medicine)
▶Date: 5:00 PM/July 24(Wed.)/2019
▶Place: Room 418, Chemistry Bldg.
Most secreted and membrane-anchored proteins synthesized at the endoplasmic reticulum (ER) contain short cleavable N-terminal hydrophobic signal sequence that varies widely in the primary structure. The signal sequence has been considered only as a sorting signal that mediates specific targeting of client proteins to the endoplasmic reticulum (ER). However, recent studies have uncovered many exceptional regulatory functions of signal sequence; protein translocation, degradation, processing, co-translational folding and topogenesis. Here, we provide a functional rationale for this long-observed sequence diversity by demonstrating that differences among signal sequences facilitate substrate-selective modulation of protein translocation and degradation. This study gives an insight into the therapeutic regulation of signal sequence efficiency as a potential strategy for human diseases associated with proteostasis deficiency.
*Keywords: ER stress, signal sequence, translocation, pre-emptive quality control, prion
▶Inquiry: Prof. Cheol-Sang Hwang (279-2352)