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생명과학과_IBB 신임교원 채용 후보 공개세미나
[Life Sciences_IBB Faculty Candidate Seminar Notice]
▶Subject: Systems biology of signal transduction: thresholds and ultrasensitivity from negative cooperativity
▶Speaker: Sang Hoon Ha, Ph.D. (Department of Chemical and Systems Biology, Stanford University)
▶Date: 4:00 PM/June. 20(Mon.)/2016
▶Place: Auditorium(1F), Postech Biotech Center
Negative cooperativity is a phenomenon where the binding of one or more molecules of a ligand to a multimeric receptor makes it more difficult for subsequent ligand molecules to bind. It is well appreciated that negative cooperativity can make a multimeric receptor’s response more graded than it would otherwise be. Here we show, through theory and experiment, that if the ligand binds the receptor with high affinity and can be appreciably depleted by receptor binding, then negative cooperativity can produce a qualitatively different type of response: a highly ultrasensitive response, with a pronounced threshold. Since ultrasensitivity and thresholds are important for generating various complex systems-level behaviors, including bistability and oscillations, the present work suggests that negative cooperativity may be important ingredient in many types of biological response.