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[BK21 Plus Seminar]
▶Subject: The roles of polarity proteins during epithelial remodeling and embryogenesis
▶Speaker: Sang-Wook Cha, PH.D.
(Division of Developmental Biology, Cincinnati Children’s Hospital Medical Center)
▶Place: Life Science Bldg. #207
During early vertebrate development, epithelial cells establish and maintain apicobasal polarity, failure of which can cause developmental defects or cancer metastasis. This process has been mostly studied in simple epithelia that have only one layer of cells, but is poorly understood in stratified epithelia. Recently, we address the roles of the polarity proteins in different contexts of developing epithelia. First, we investigate the role of Partitioning defective-6 homolog beta (Par6b) in the developing stratified epidermis of Xenopus laevis. Par6b is required to maintain the "basolateral“ state in both epidermal layers, which explains the reduction of basolateral adhesion complexes and epidermal cells shedding. Second, we choose Xenopus oocyte, single spherical cell, as a model to study the roles of polarity proteins within a cell. The Xenopus oocyte contains components of both the planar cell polarity and apical-basal polarity pathways, but their roles are not known. This study demonstrates the interaction and interdependence of Vangl2, VAMP1, aPKC and the stable microtubule cytoskeleton in the oocyte, shows that maternal Vangl2 and aPKC are required for specific oocyte asymmetries and vertebrate embryonic patterning. More recently, we investigate how either solid endoderm tissue in Xenopus or cuboidal epithelium in mammals turns into pseudostratified epithelium. we show that Wnt signal that emanates from surrounding mesenchyme activates planar cell polarity components in endodermal cell, which in turn regulates the establishment of polarized epithelium by controlling the activity of apicobasal polarity complexes. Taken together, various polarity proteins regulate epithelial remodeling process and have a distinct role in a context-dependent manner.
▶Inquiry: Prof. Han, Jin Kwan (279-2126)
* This seminar will be given in English.
please refrain from taking photos during seminars. *