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Hormonal control of genome integrity in Arabidopsis roots

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  • 2017-01-06


[2016 Fall Life Sciences & IBB Regular Seminar]
                        ▶Subject: Hormonal control of genome integrity in Arabidopsis roots
                        ▶Speaker: Prof. Masaaki Umeda (Nara Institute of Science and Technology)
                        ▶Date: 4:30PM/Dec. 16(Fri.)/2016
                        ▶Place: Auditorium(1F), POSTECH Biotech Center
                      Cell division is suppressed in response to environmental stress to minimize energy consumption in organ growth. Under such circumstances, plants control the duration of the cell cycle and the transition from the mitotic cell cycle to the endocycle, in which DNA replication is repeated without mitosis or cytokinesis. DNA is constantly damaged during DNA replication, while various internal and external stimuli cause further DNA damage; for example, reactive oxygen species produced by photosynthesis, high aluminum or boron levels in soil, and pathogen attack are known to damage DNA. In animals, severe DNA damage causes cell death, but we previously reported that, in plants, genotoxic stress promotes the endocycle onset of dividing cells, and that only stem cells and their daughters undergo cell death. In Arabidopsis roots, dead stem cells are replaced by newly generated cells from the quiescent center, in which cell division is activated upon DNA damage. This represents an elaborate mechanism preserving stem cells under stressful conditions. I will present how these responses to DNA damage are mediated by hormonal signaling, and propose that plants deploy distinct mechanisms controlling cell division and cell death to maintain genome integrity under changing environmental conditions.

                    ▶Inquiry: Prof. Il-Doo Hwang (T. 279-2291)
                          * This seminar will be given in English.
                      please refrain from taking photos during seminars. *

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